Joi and Blokes | USA Website

Name: Joi and Blokes Review | Compounded GLP-1 Telehealth Clinic
Creator: John M.

📅 Last Updated: July 07, 2026

Written by John M.

Health & Wellness Product Researcher · 5+ Years Experience

John has spent over 5 years researching and reviewing health and fitness products. This review of the Joi and Blokes platform is based on in-depth analysis of customer feedback, expert opinions, and thorough research across multiple trusted sources.

Joi and Blokes operates dual-brand longevity clinics — Joi for women and Blokes for men — offering hormone therapy, peptides, and NAD+ treatment. The NAD+ offering sits within a broader performance and longevity catalog, which gives it clinical credibility beyond a standalone NAD+ platform.

Research on NAD+ supports its role in cellular energy and longevity pathways. NAD+ declines with age and supplementation may support mitochondrial function and DNA repair — mechanisms that make clinical-grade delivery formats meaningfully more effective than oral supplements.

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Made In USA

Our Joi and Blokes medications are proudly formulated in the United States of America.

GMP Certified

Good Manufacturing Practice certified ensuring pharmaceutical grade quality.

FDA Registered Facility

Joi and Blokes partner compounding pharmacies adhere to strict state and federal safety standards.

Safe & Researched

Compounded GLP-1 medications are carefully prescribed and monitored under strict medical supervision.

— Christopher L.

⭐⭐⭐⭐⭐ Verified Purchase
“I was looking for a more convenient way to manage my wellness routine, and this made the process much easier. Everything felt organized and straightforward.”

— Olivia C.

⭐⭐⭐⭐⭐ Verified Purchase
“The platform was easy to navigate, and I appreciated how smooth the onboarding process was. Definitely worth checking out if you're looking for a hassle-free wellness service.”

— Natalie R.

⭐⭐⭐⭐⭐ Verified Purchase
“The whole process was simple from start to finish. I liked being able to complete everything online, and the support team was responsive whenever I had questions.”

Joi and Blokes is a U.S.-based telehealth platform founded by Josh and Katy Whalen. Joi serves women and Blokes serves men. Both run on the same clinical infrastructure. The platform’s core offering has always been hormone optimization including bioidentical HRT for women and testosterone replacement for men. GLP-1 weight loss programs were added as part of a broader wellness expansion.

The compounded GLP-1 program gives patients access to compounded formulations containing either semaglutide (a GLP-1 receptor agonist) or tirzepatide (a dual GLP-1 and GIP receptor agonist). These are not brand-name Ozempic, Wegovy, Mounjaro or Zepbound. They are compounded versions prepared by licensed compounding pharmacies and they have not been individually reviewed by the FDA for safety, efficacy or quality as finished products. Joi and Blokes discloses this on their product page which is the minimum standard any responsible platform should meet.

The program operates across all 50 states though compounded semaglutide is not available in every state.

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The process is fully virtual. There is no in-person visit required at any stage.

After enrolling you complete an online health intake and are matched with a licensed provider through one of Joi and Blokes’ partner clinicians. The provider reviews your health history asynchronously which means you will not necessarily have a live video call. If you are deemed a candidate a prescription is sent to one of their compounding pharmacy partners. Known pharmacy partners include Empower Pharmacy and Tailor Made Compounding in Nicholasville, KY.

Once approved and payment is confirmed medication typically arrives within 72 hours. Semaglutide and tirzepatide are both subcutaneous injections administered once weekly into the fatty tissue of the abdomen, upper arm or thigh. Needle size is insulin-scale which most patients find manageable.

Dosing follows a gradual titration schedule starting low and increasing incrementally to minimise gastrointestinal side effects while the body adjusts. The specific concentration and any additional compounded ingredients such as B12, glycine or L-carnitine depend on the prescribing clinician’s assessment of your individual needs.

Both semaglutide and tirzepatide options available: Patients can access either a GLP-1-only formulation (semaglutide) or a dual GLP-1/GIP formulation (tirzepatide) depending on clinical assessment. Tirzepatide has shown stronger average weight loss outcomes in clinical trial data though individual results vary considerably.
Health coaching included: Every program includes access to a dedicated health coach. Coaches come from backgrounds including nursing, dietetics, personal training and naturopathic medicine. They are not prescribers but they act as a liaison between you and your clinical team and provide lifestyle guidance throughout treatment.
HSA/FSA eligible: Joi and Blokes will provide a Letter of Medical Necessity (LMN) and detailed receipts to support HSA or FSA reimbursement claims. Coverage depends on your specific plan.
Add-on ingredients: Compounded formulations may include B12, glycine or L-carnitine based on individual clinical needs. These are ingredients some providers include to support tolerability or metabolic function.
Broad telehealth ecosystem: Because Joi and Blokes is a full hormone health platform GLP-1 patients can also access lab panels, HRT or TRT, thyroid care, NAD+ and peptides without switching providers.
No labs required to start: Unlike some competitors who mandate baseline labs before prescribing, Joi and Blokes treats labs as optional for GLP-1 patients. Panels ranging from $149 to $399 are available for those who want a fuller clinical picture.

Pros of Joi and Blokes

• Both semaglutide and tirzepatide are available
• Health coaching is included at no extra cost
• HSA/FSA accepted with LMN support
• Full-spectrum hormone health platform covering multiple needs under one provider
• Discounted first month (semaglutide $99, tirzepatide $149)
• No labs required to get started
• Named medical advisory team including Dr. Melissa Loseke (DO, PhD)

Knowing exactly what the subscription covers is critical before you commit.

What the monthly subscription includes:

• Virtual consultations with a licensed provider
• Personalized health coaching
• Dosing guidance and titration support
• Ongoing clinical check-ins
• Access to lab testing (at additional cost)

What is not included:

• The medication itself
This is the detail that catches many new patients off guard. The subscription fee covers the program infrastructure and you pay for the medication separately through the compounding pharmacy. That separation significantly changes the real monthly cost.

Personalized Treatment Plans: Joi and Blokes doesn't rely on a one-size-fits-all approach. Your treatment plan is created based on your health history, symptoms, goals, and diagnostic results, allowing recommendations to be tailored to your individual needs.
Advanced Lab Testing & Biomarker Analysis: The platform uses comprehensive lab testing to evaluate biomarkers such as hormones, metabolism, and other health indicators. These insights help clinicians better understand your health and recommend an appropriate care plan.
Licensed Healthcare Professionals: You'll work with licensed clinicians through virtual consultations. They review your lab results, discuss your symptoms and goals, answer your questions, and recommend treatment options when appropriate.
Convenient Telehealth Experience: Everything can be managed online—from completing your health history and scheduling appointments to virtual consultations and follow-up care. This makes it easier to access care without visiting a clinic in person.
Ongoing Health Monitoring: Rather than focusing on a single appointment, Joi and Blokes supports ongoing care. Your progress can be monitored over time, and treatment recommendations may be adjusted based on follow-up evaluations and updated lab results.
Comprehensive Wellness Services: The platform offers services across multiple areas of health, including hormone optimization, weight management, longevity, men's health, women's health, and wellness support, depending on your needs and eligibility.
Prescription Fulfillment & Home Delivery: If a clinician determines that prescription treatment is appropriate, eligible medications can be fulfilled through partner pharmacies and delivered directly to your home, making the process more convenient.
Human Guidance with Data-Driven Insights: Joi and Blokes combines diagnostic data with clinician expertise. Rather than simply providing lab numbers, clinicians help explain the results and discuss practical next steps that fit your health goals.

Compounded medications use the same active ingredients as their brand-name equivalents but the finished compounded product has not gone through the FDA’s approval process. That is a meaningful regulatory distinction and something every patient should understand clearly before starting.

The most commonly reported side effects with both semaglutide and tirzepatide are:

• Nausea and vomiting
• Diarrhoea or constipation
• Bloating and gas
• Fatigue
• Injection site reactions
• Decreased appetite (expected)
• Belching or heartburn

Most side effects are dose-dependent and tend to improve as the body adjusts. They are most common when the dosage is increased and generally settle once a stable dose is reached. The gradual titration protocol is specifically designed to reduce their intensity.

More serious risks including pancreatitis and thyroid changes exist but are rare. Anyone with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome should not use GLP-1 medications. Always discuss your full health history with the prescribing provider before starting.

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GLP-1 medications are not fast-acting in the way older appetite suppressants were. Results build over months not weeks.

• Weeks 1 to 4: Most patients notice reduced appetite and fewer cravings. Some experience more noticeable GI side effects early on. Scale movement is often modest at this stage.

• Months 2 to 3: Appetite regulation tends to stabilize. Many patients report food no longer occupying constant mental space which is a qualitative shift that often precedes visible weight changes.

• Months 3 to 6: Meaningful weight loss becomes more consistent for most patients. Clinical trial data on tirzepatide show average losses of 15 to 20.9% of body weight over 72 weeks across dose levels in adults without diabetes. Semaglutide trials show approximately 12 to 15% average loss over a similar period.

• Beyond 6 months: Sustained results depend heavily on lifestyle factors including diet, movement and sleep. The health coach component is designed to support habit formation during this phase with the goal of maintaining progress even after medication is eventually tapered or stopped.

Individual results vary and clinical averages are useful context not personal guarantees.

For the right patient the answer is yes but only with a clear-eyed view of what you are buying.

If you are already using Joi and Blokes for hormone therapy adding GLP-1 to your existing relationship makes practical sense. The health coaching is genuinely included, the platform has clinical credibility and managing weight and hormones together can produce results that neither approach achieves alone.

If GLP-1 is the only reason you are considering Joi and Blokes the calculus is harder. The quarterly billing structure means your first three months cost $497 for semaglutide before medication. Once medication is added you are approaching $550 to $600 per month. Competitors like Ro offer monthly billing at a lower headline price and that flexibility matters if you are uncertain about tolerability or early results.

Joi and Blokes offers a legitimate and clinically structured compounded GLP-1 program with real health coaching, a credible medical team and access to both semaglutide and tirzepatide. The platform’s strength is its breadth. For patients who want hormone and weight management under one telehealth roof it genuinely delivers more than a standalone GLP-1 provider can.

The key things to go in with eyes open about are the quarterly billing lock-in, the medication cost sitting entirely outside the subscription fee and the 2026 regulatory environment around compounded GLP-1. The FDA’s proposed removal of semaglutide and tirzepatide from the 503B bulks list is a real development. Any patient enrolling now should ask Joi and Blokes directly about the current legal and regulatory basis for compounded availability in their state.

If the pricing model works for you and you have read the terms carefully it is a well-run platform with a track record to back it up.

How to Get Started?

1. Visit the Joi and Blokes GLP-1 official website and select semaglutide or tirzepatide

2. Add the program to your cart and complete the health intake form

3. A licensed provider reviews your history and contacts you about prescription eligibility

4. If approved arrange payment through the compounding pharmacy

5. Medication ships directly to your address typically within 72 hours of approval

6. Your health coach schedules a welcome call to walk you through dosing and support

If a clinician determines you are not a candidate for GLP-1 medication the platform states your subscription will be cancelled and a refund will be issued for that scenario specifically.

Joi and Blokes® 180-Days Money Back Guarantee

The Joi and Blokes is backed by a 100% money back guarantee for 180 full days from your original purchase.

If you’re not totally and completely satisfied with the Joi and Blokes, or your experience in the first 180 days from your purchase and we’ll give you a refund within 48 hours of the product being returned.

That’s right, simply return the Joi and Blokes, anytime within 180 days of your purchase and you’ll receive a refund, no questions asked!

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Is Joi and Blokes compounded semaglutide the same as Ozempic or Wegovy?

No. It uses the same active ingredient but is a compounded product and has not been reviewed by the FDA for safety, efficacy or quality. Ozempic and Wegovy are FDA-approved drugs made by Novo Nordisk.

Can I use my HSA or FSA?

Yes. Joi and Blokes provides a Letter of Medical Necessity and detailed receipts for reimbursement. Eligibility depends on your plan.

What happens if I am not approved for GLP-1 medication?

Your subscription will be cancelled and a refund issued per the company’s stated refund policy.

How does Joi and Blokes compare to Ro or Hims?

Ro ($149/month) and Hims ($199/month) both bill monthly and medication is included. Joi and Blokes bills quarterly at $199/month with medication priced separately. Better value if you need hormone support alongside GLP-1. Less flexible if weight loss is your only goal.

Can I cancel at any time?

Only after the initial 3-month commitment. Written notice is required at least 30 days before the next billing date. Fees already paid are non-refundable.

Is my information private?

Joi and Blokes runs the process through your portal account and ships discreetly, keeping a sensitive concern between you and your provider.

Joi and Blokes | USA Website